TCONS_00483150 as a novel diagnostic biomarker of systemic lupus erythematosus.
Gangqiang GuoAqiong ChenLele YeHuijing WangZhiyuan ChenKejing YanXinyu ShiBaoqing LiQiaoai LinXiaohan YouCizhong JiangQingfeng ZhangXiaokai DingXiang-Yang XueHuidi ZhangPublished in: Epigenomics (2020)
Aim: We aimed to identify differentially expressed Long noncoding RNAs (lncRNAs) and explore their functional roles in systemic lupus erythematosus (SLE). Materials & methods: We identified dysregulated lncRNAs and investigated their prognostic values and potential functions using MiRTarget2, catRAPID omics and Bedtools/blast/Pearson analyses. Results: Among the 143 differentially expressed lncRNAs, TCONS_00483150 could be used to distinguish patients with SLE from healthy controls and those with rheumatoid arthritis and patients with active/stable SLE from healthy controls. TCONS_00483150 was significantly correlated with anti-Rib-P antibody positivity and low C3 levels; TCONS_00483150 dysregulation might contribute to the metabolism of RNA and proteins in SLE patients. Conclusion: Overall, our findings offer a transcriptome-wide overview of aberrantly expressed lncRNAs in patients with SLE and highlight TCONS_00483150 as a potential novel diagnostic biomarker.
Keyphrases
- systemic lupus erythematosus
- disease activity
- rheumatoid arthritis
- network analysis
- end stage renal disease
- ankylosing spondylitis
- genome wide analysis
- ejection fraction
- genome wide identification
- newly diagnosed
- single cell
- prognostic factors
- gene expression
- human health
- dna methylation
- genome wide
- interstitial lung disease
- nucleic acid