Therapeutics in Osteoarthritis Based on an Understanding of Its Molecular Pathogenesis.
Ju-Ryoung KimJong Jin YooHyun Ah KimPublished in: International journal of molecular sciences (2018)
Osteoarthritis (OA) is the most prevalent joint disease in older people and is characterized by the progressive destruction of articular cartilage, synovial inflammation, changes in subchondral bone and peri-articular muscle, and pain. Because our understanding of the aetiopathogenesis of OA remains incomplete, we haven't discovered a cure for OA yet. This review appraises novel therapeutics based on recent progress in our understanding of the molecular pathogenesis of OA, including pro-inflammatory and pro-catabolic mediators and the relevant signalling mechanisms. The changes in subchondral bone and peri-articular muscle accompanying cartilage damage are also reviewed.
Keyphrases
- knee osteoarthritis
- bone mineral density
- oxidative stress
- skeletal muscle
- rheumatoid arthritis
- small molecule
- chronic pain
- multiple sclerosis
- bone loss
- soft tissue
- neuropathic pain
- bone regeneration
- single molecule
- pain management
- postmenopausal women
- anti inflammatory
- spinal cord
- spinal cord injury
- postoperative pain