HDAC6 involves in regulating the lncRNA-microRNA-mRNA network to promote the proliferation of glioblastoma cells.

An-Chih WuWen-Bin YangKwang-Yu ChangJung-Shun LeeJing-Ping LiouRuei-Yuan SuSiao Muk ChengDaw-Yang HwangUshio KikkawaTsung-I HsuChih-Yang WangWen-Chang ChangPin-Yuan ChenJian-Ying Chuang

Published in: Journal of experimental & clinical cancer research : CR (2022)

This study sheds light on the role of LINC00461 in GBM malignancy and provides a novel therapeutic strategy for targeting the HDAC6/RBP/LINC00461 axis and its downstream effectors in patients with GBM.

Keyphrases

long non coding rna
long noncoding rna
induced apoptosis
cell proliferation
histone deacetylase
signaling pathway
cell cycle arrest
cancer therapy
endoplasmic reticulum stress
cell death
oxidative stress
binding protein
type iii
network analysis