Natural non-homologous recombination led to the emergence of a duplicated V3-NS5A region in HCV-1b strains associated with hepatocellular carcinoma.
Hélène Le Guillou-GuillemetteAdeline PivertElise BouthryCécile HenquellOdile PetsarisAlexandra DucancellePascal VeillonSophie ValletSophie AlainVincent ThibaultFlorence AbravanelArielle A RosenbergElisabeth André-GarnierJean-Baptiste BourYazid BaaziaPascale TrimouletPatrice AndréCatherine Gaudy-GraffinDominique BettingerSylvie LarratAnne Signori-SchmuckHénia SaoudinBruno PozzettoGisèle LagathuSophie Minjolle-ChaFrançoise Stoll-KellerJean-Michel PawlotskyJacques IzopetChristopher PayanFrançoise Lunel-FabianiChristophe LemairePublished in: PloS one (2017)
These results emphasize the possible consequences of non-homologous recombination in the emergence and severity of new viral diseases.