Histone Methylation and Oxidative Stress in Cardiovascular Diseases.
Xin YiQiu-Xia ZhuXing-Liang WuTuan-Tuan TanXue-Jun JiangPublished in: Oxidative medicine and cellular longevity (2022)
Oxidative stress occurs when ROS overproduction overwhelms the elimination ability of antioxidants. Accumulated studies have found that oxidative stress is regulated by histone methylation and plays a critical role in the development and progression of cardiovascular diseases. Targeting the underlying molecular mechanism to alter the interplay of oxidative stress and histone methylation may enable creative and effective therapeutic strategies to be developed against a variety of cardiovascular disorders. Recently, some drugs targeting epigenetic modifiers have been used to treat specific types of cancers. However, the comprehensive signaling pathways bridging oxidative stress and histone methylation need to be deeply explored in the contexts of cardiovascular physiology and pathology before clinical therapies be developed. In the present review, we summarize and update information on the interplay between histone methylation and oxidative stress during the development of cardiovascular diseases such as atherosclerosis, coronary artery disease, pulmonary hypertension, and diabetic macro- and microvascular pathologies.
Keyphrases
- oxidative stress
- dna methylation
- cardiovascular disease
- dna damage
- genome wide
- induced apoptosis
- diabetic rats
- ischemia reperfusion injury
- coronary artery disease
- pulmonary hypertension
- type diabetes
- signaling pathway
- cell proliferation
- heart failure
- atrial fibrillation
- cardiovascular risk factors
- percutaneous coronary intervention
- social media
- pi k akt
- pulmonary arterial hypertension
- left ventricular
- cardiovascular events
- health information