PI3Kδ inhibition potentiates glucocorticoids in B-ALL by decreased receptor phosphorylation and enhanced gene regulation.

Jessica A O ZimmermanMimi FangMiles A Pufall

Published in: bioRxiv : the preprint server for biology (2023)

Idelalisib potentiates glucocorticoids in B-ALL in part by reducing GR phosphorylation and enhancing gene regulationInhibition of tissue-restricted PI3Kδ likely allows durable potentiation expressly in B-ALL, even as the glucocorticoid is cleared.

Keyphrases

protein kinase
copy number
genome wide
genome wide identification
gene expression
transcription factor
genome wide analysis