Lower circulating neuron-specific enolase concentrations in adults and adolescents with severe mental illness.

Dimitrios AndreouNils Eiel SteenKjetil Nordbø JørgensenRunar Elle SmelrorKirsten Wedervang-ResellStener NerlandLars T WestlyeTerje NærlandAnne Margrethe MyhreInge JoaSolveig Merete Klæbo ReitanArne VaalerGunnar MorkenErlend BøenTorbjørn ElvsåshagenBirgitte BoyeUlrik Fredrik MaltPål AukrustSilje SkredeRune Andreas KrokenErik JohnsenSrdjan DjurovicOle A AndreassenThor UelandIngrid Agartz

Published in: Psychological medicine (2021)

We found lower NSE concentrations in adult and adolescent patients with SMI compared to HC. The results suggest the lack of progressive neuronal injury, and may reflect abnormal neuronal maturation. This provides further support of a neurodevelopmental rather than a neurodegenerative mechanism in SMI.

Keyphrases

mental illness
mental health
young adults
childhood cancer
multiple sclerosis
cerebral ischemia
physical activity