Role of microsatellite instability and HER2 positivity in locally advanced esophago-gastric cancer patients treated with peri-operative chemotherapy.
Lorenzo GervasoLuca BottiglieriMonica Isabel Meneses-MedinaStefania PellicoriRoberto BiffiUberto Fumagalli RomarioStefano De PascaleIsabella SalaVincenzo BagnardiMassimo BarberisChiara Alessandra CellaNicola FazioPublished in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2023)
Our work confirms the positive prognostic effect of MSI-H in the curative setting of LAGC, not correlated with pathologic tumor downstaging. Prospective ad-hoc trial and tumor molecular profiling are eagerly needed.