Correlation of TcII discrete typing units with severe chronic Chagas cardiomyopathy in patients from various Brazilian geographic regions.

Maykon Tavares de OliveiraCarlos Alessandro FuzoMaria Cláudia da SilvaEduardo Antônio DonadiJoão Santana da SilvaHenrique Turin MoreiraAndré SchmidtJosé Antônio Marin-Neto

Published in: PLoS neglected tropical diseases (2022)

Our data corroborate previous findings, indicating the predominance of the TcII genotype in patients with CCC of Brazilian origin. Moreover, this study pioneered disclosing a direct correlation between the TcII DTU and severe CCC.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
early onset
heart failure
prognostic factors
drug induced
patient reported outcomes
electronic health record
big data
machine learning
atrial fibrillation
genetic diversity