Association of beta-hydroxybutyrate with development of heart failure: Sex differences in a Dutch population cohort.
Jose-Luis Flores GuerreroBerend Daan WestenbrinkMargery A ConnellyJames D OtvosDion GroothofIrina ShalaurovaErwin GarciaGerjan NavisRudolf A de BoerStephan J L BakkerRobin P F DullaartPublished in: European journal of clinical investigation (2020)
This prospective study suggests that high plasma concentrations of β-OHB are associated with an increased risk of HFrEF, particularly in women. The mechanisms responsible for the sex differences of this association warrant further study.