Intrahepatic immune changes after hepatitis c virus eradication by direct-acting antiviral therapy.

Giuliana AmaddeoCong Trung NguyenPascale MailléSebastien MuléAlain LucianiCamilia MachouAurélie RodriguesHélène RegnaultAriane MallatAlexis LaurentFouad LafdilChristophe HézodeJean-Michel PawlotskyJulien Calderaro

Published in: Liver international : official journal of the International Association for the Study of the Liver (2019)

In conclusion, removal of HCV infection after DAA-based therapy results only in a down-regulation of interferon-stimulated genes in non-tumoral tissues from patients with cirrhosis who develop HCC. These minor changes in the liver immune microenvironment are unlikely to favour HCC occurrence or recurrence after DAA-induced SVR.

Keyphrases

hepatitis c virus
human immunodeficiency virus
gene expression
risk assessment
dendritic cells
genome wide
drug induced
oxidative stress
endothelial cells
bone marrow
genome wide analysis