SABRE hyperpolarized anticancer agents for use in 1 H MRI.

Elizabeth J Fear Aneurin J Kennerley Peter J Rayner Philip L Norcott Soumya S Roy Simon B Duckett

Published in: Magnetic resonance in medicine (2022)

Here, we demonstrate the power of SABRE to deliver a fast and cost-effective route to hyperpolarization of important chemical motifs of anticancer agents. The SABRE approach outlined here lays the foundations for realizing continuous flow, hyperpolarized tracking of drug delivery/pathways.

Keyphrases

drug delivery
contrast enhanced
cancer therapy
diffusion weighted imaging
magnetic resonance
drug release