Stress testing the Centiloid: Precision and variability of PET quantification of amyloid pathology.

Mahnaz Shekari David Vállez García Lyduine E Collij Daniele Altomare Fiona Heeman Hugh G PembertonNúria Roé VellvéSantiago BullichChristopher BuckleyAndrew StephensGill Farrar Giovanni Battista Frisoni William E Klunk Frederik Barkhof Juan-Domingo Gispertnull null

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)

We developed a framework for evaluating Centiloid (CL) variability to different factors. Reference region selection and delineation had the highest impact on CL values. Whole cerebellum (WCB) and whole cerebellum plus brainstem (WCB+BSTM) as reference regions yielded consistent results across tracers. The standard CL pipeline is robust against atrophy and image resolution variation. Estimated within- and between-pipeline variability (95% confidence interval) in absolute CL units.

Keyphrases

computed tomography
deep learning
positron emission tomography
single molecule
machine learning