Stress testing the Centiloid: Precision and variability of PET quantification of amyloid pathology.
Mahnaz ShekariDavid Vállez GarcíaLyduine E CollijDaniele AltomareFiona HeemanHugh G PembertonNúria Roé VellvéSantiago BullichChristopher BuckleyAndrew StephensGill FarrarGiovanni Battista FrisoniWilliam E KlunkFrederik BarkhofJuan-Domingo Gispertnull nullPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
We developed a framework for evaluating Centiloid (CL) variability to different factors. Reference region selection and delineation had the highest impact on CL values. Whole cerebellum (WCB) and whole cerebellum plus brainstem (WCB+BSTM) as reference regions yielded consistent results across tracers. The standard CL pipeline is robust against atrophy and image resolution variation. Estimated within- and between-pipeline variability (95% confidence interval) in absolute CL units.