Laser ablation inductively coupled plasma mass spectrometry as a novel clinical imaging tool to detect asbestos fibres in malignant mesothelioma.
Oana M VoloacaCalum J GreenhalghLaura M ColeMalcolm R ClenchAmy J ManaghSarah Louise Haywood-SmallPublished in: Rapid communications in mass spectrometry : RCM (2021)
Detection of asbestos fibres in lung tissues is very useful, if not necessary, to complete the pathological dt9iagnosis of asbestos-related malignancies in the medicolegal field. For the first time, this study demonstrates the successful application of LA-ICP-MS imaging to identify asbestos fibres and other mineral fibres within mesothelioma samples. Ultimately, high-resolution, fast-speed LA-ICP-MS analysis has the potential to be integrated into clinical workflow to aid earlier detection and stratification of mesothelioma patient samples.
Keyphrases
- high resolution
- mass spectrometry
- liquid chromatography
- high performance liquid chromatography
- capillary electrophoresis
- multiple sclerosis
- loop mediated isothermal amplification
- gas chromatography
- high speed
- real time pcr
- tandem mass spectrometry
- gene expression
- label free
- electronic health record
- case report
- human health
- atrial fibrillation
- sensitive detection
- drug induced
- solid phase extraction