Platelet LGALS3BP Induces Myeloid Inflammation In Systemic Lupus Erythematosus.

Hanane El Bannoudi MacIntosh Grant CornwellElliot Luttrell-WilliamsAlexis EngelChristina RollingTessa J BarrettPeter IzmirlyH Michael BelmontKelly RugglesRobert ClancyJill P BuyonJeffrey S Berger

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2022)

These data support that platelets act as potent effector cells contributing to the pathogenesis of SLE by secreting proinflammatory LGALS3BP, which also represents a novel biomarker of SLE clinical activity.

Keyphrases

systemic lupus erythematosus
induced apoptosis
disease activity
dendritic cells
oxidative stress
cell cycle arrest
bone marrow
electronic health record
acute myeloid leukemia
regulatory t cells
endoplasmic reticulum stress
signaling pathway
machine learning
cell proliferation
deep learning