Copper oxide nanoparticles trigger macrophage cell death with misfolding of Cu/Zn superoxide dismutase 1 (SOD1).
Govind GuptaFrancesca CappelliniLucian FarcalRosalba GornatiGiovanni BernardiniBengt FadeelPublished in: Particle and fibre toxicology (2022)
CuO NPs undergo dissolution in lysosomes leading to copper-dependent macrophage cell death characterized by protein misfolding and proteasomal insufficiency. Specifically, we present novel evidence for Cu-induced SOD1 misfolding which accords with the pronounced oxidative stress observed in CuO NP-exposed macrophages. These results are relevant for our understanding of the consequences of inadvertent human exposure to CuO NPs.
Keyphrases
- oxide nanoparticles
- cell death
- oxidative stress
- diabetic rats
- endothelial cells
- high glucose
- amyotrophic lateral sclerosis
- adipose tissue
- cell cycle arrest
- aqueous solution
- heavy metals
- dna damage
- induced pluripotent stem cells
- ischemia reperfusion injury
- nitric oxide
- induced apoptosis
- risk assessment
- heat shock protein