With the development of transfusion medicine, platelet pathogen contamination is of increasing concern to the industry. Currently, pathogen reduction technology (PRT) has been successfully applied to platelets and achieved good results. This paper provides an overview of the research progress of commercial platelet PRT, a comprehensive analysis of the current application status of platelet PRT, preclinical mechanism studies, clinical cohort studies and alternative or complementary strategies, and makes recommendations to provide a scientific basis for safeguarding blood safety in China and developing platelet PRT products applicable to our national conditions.