Sialic acid metabolism orchestrates transcellular connectivity and signalling in glioblastoma.

Ugne KuliesiuteKevin JosephJakob StraehleVidhya Madapusi RaviJan KueckelhausJasim Kada BenotmaneJunyi ZhangAndreas VlachosJuergen BeckOliver SchnellUrte NeniskyteDieter Henrik Heiland

Published in: Neuro-oncology (2023)

Our results indicate that sialic acid is essential for the establishment of GBM tumor and its cellular network. They highlight the importance of sialic acid for glioblastoma pathology and suggest that dynamics of sialylation have the potential to be targeted therapeutically.

Keyphrases

multiple sclerosis
white matter
resting state
functional connectivity
cancer therapy
human health
risk assessment