Neferine Targeted the NLRC5/NLRP3 Pathway to Inhibit M1-type Polarization and Pyroptosis of Macrophages to Improve Hyperuricemic Nephropathy.

Wei YinJin-Hua WangYu-Mei LiangKang-Han LiuYing ChenYusa Chen

Published in: Current molecular medicine (2024)

Nef improved HN by inhibiting macrophages polarized to M1-type and pyroptosis by targeting the NLRC5/NLRP3 pathway. This research provides a scientific theoretical basis for the treatment of HN.

Keyphrases

nlrp inflammasome
cancer therapy
uric acid
metabolic syndrome
replacement therapy