Mechanical force induces mitophagy-mediated anaerobic oxidation in periodontal ligament stem cells.
Zijie ZhangShuyue CuiYajing FuJixiao WangJiani LiuFulan WeiPublished in: Cellular & molecular biology letters (2023)
Altogether, our study demonstrates that PDLSCs under mechanical force preferred anaerobic oxidation induced by the affected mitochondrial dynamics, especially mitophagy. Our findings support an association between mechanical stimulation and the oxidative profile of stem cells, which may shed light on the mechanical guidance of stem cell maintenance and commitment, and lay a molecular foundation for periodontal tissue regeneration.