Retinoic acid promotes differentiation of WiT49- but not of CCG99-11 Wilms tumour cells.

Caroline JanssonLinda Holmquist Mengelbier

Published in: Cancer reports (Hoboken, N.J.) (2023)

Our study shows that in vitro culturing of WiT49 and CCG99-11 cells, followed by pelleting and paraffin embedding of cell pellets, could aid in a quick evaluation of potential differentiating agents against Wilms tumour. In addition, our results strengthen previous results that retinoic acid could be a potential complement to regular Wilms tumour treatment.

Keyphrases

induced apoptosis
cell cycle arrest
oxidative stress
endoplasmic reticulum stress
human health
magnetic resonance
pi k akt