Putative therapeutic impacts of cardiac CTRP9 in ischaemia/reperfusion injury.
Seyyed-Reza Sadat-EbrahimiHassan AminiReza RahbarghaziParia HabibollahiShahrouz GhaderiHadi RajabiAysa RezabakhshPublished in: Journal of cellular and molecular medicine (2022)
Recently, cytokines belonging to C1q/tumour necrosis factor-related proteins (CTRPs) superfamily have attracted increasing attention due to multiple metabolic functions and desirable anti-inflammatory effects. These various molecular effectors exhibit key roles upon the onset of cardiovascular diseases, making them novel adipo/cardiokines. This review article aimed to highlight recent findings correlated with therapeutic effects and additional mechanisms specific to the CTRP9, particularly in cardiac ischaemia/reperfusion injury (IRI). Besides, the network of the CTPR9 signalling pathway and its possible relationship with IRI were discussed. Together, the discovery of all involved underlying mechanisms could shed light to alleviate the pathological sequelae after the occurrence of IRI.
Keyphrases
- cerebral ischemia
- acute myocardial infarction
- cardiovascular disease
- left ventricular
- acute ischemic stroke
- risk assessment
- small molecule
- working memory
- high throughput
- type diabetes
- blood brain barrier
- transcription factor
- atrial fibrillation
- acute coronary syndrome
- cardiovascular risk factors
- coronary artery disease