An Autologous Dendritic Cell Vaccine Promotes Anticancer Immunity in Patients with Ovarian Cancer with Low Mutational Burden and Cold Tumors.
Jitka FucikovaMichal HenslerLenka KasikovaTereza LanickovaJosef PasulkaJana RakovaJana DrozenovaTessa FredriksenMarek HraskaTereza HrnciarovaKlara SochorovaDaniela RozkovaLudek SojkaPavel DundrJan LacoTomas BrtnickyIvan PraznovecMichael Jiří HalaškaLukáš RobAleš RyškaAn CoosemansIgnace VergoteDavid CibulaJirina BartunkovaJerome GalonLorenzo GalluzziRadek SpisekPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
Our findings suggest that while patients with highly infiltrated, "hot" EOCs benefit from chemotherapy, women with "cold" EOCs may instead require DC-based vaccination to jumpstart clinically relevant anticancer immune responses.