The utility of flow cytometry in differentiating NK/T cell lymphoma from indolent and reactive NK cell proliferations.
Sanjay De MelJenny Bei LiMuhammad Bilal AbidTiffany TangHui Ming TayWen Chang TingLi Mei PoonTae Hoon ChungBenjamin MowAllison TsoKiat Hoe OngWee Joo ChngTe Chih LiuPublished in: Cytometry. Part B, Clinical cytometry (2017)
It was concluded that FC can reliably distinguish NKTCL from CLPD-NK, normal NK cells of CD56+ phenotype, and RNKL. It was proposed that the typical phenotype for NKTCL is: CD56 bright, CD16 dim with positive CD2, CD7, CD94, HLADR, CD25, CD26, and absent CD57. This resembles the phenotype of the CD56 bright immunoregulatory subset of NK cells which we therefore hypothesize is the cell of origin of NKTCL. © 2017 International Clinical Cytometry Society.