Palladin promotes cancer stem cell-like properties in lung cancer by activating Wnt/Β-Catenin signaling.

Xiong ShuMeng ChenShi-Ya LiuLong YuLi-Xin SunLi-Chao SunYu-Liang Ran

Published in: Cancer medicine (2022)

Palladin might act as an oncogene by promoting CSCs-like properties and tumorigenicity of NSCLC cells via the Wnt/β-catenin signaling pathway. Besides, Palladin was identified to have the potential as a cell surface marker for LCSCs identification. These findings provide a possible target for developing putative agents targeted to LCSCs.

Keyphrases

cancer stem cells
cell surface
induced apoptosis
cell proliferation
stem cells
small cell lung cancer
signaling pathway
cell cycle arrest
cancer therapy
endoplasmic reticulum stress
oxidative stress
risk assessment
human health
bioinformatics analysis
brain metastases