Interleukin 10 Gene-Modified Bone Marrow-Derived Dendritic Cells Attenuate Liver Fibrosis in Mice by Inducing Regulatory T Cells and Inhibiting the TGF-β/Smad Signaling Pathway.
Yejin XuXinyue TangMin YangShengguo ZhangShanshan LiYukai ChenMinhui LiuYuxiang GuoMingqin LuPublished in: Mediators of inflammation (2019)
IL-10 genetic modification of BMDCs may maintain DC in the state of tolerance and allow DC to induce T cell hyporesponsiveness or tolerance. DC-IL10 suppressed liver fibrosis by inducing Treg production and inhibiting the TGF-β/smad signaling pathway.
Keyphrases
- liver fibrosis
- dendritic cells
- signaling pathway
- regulatory t cells
- transforming growth factor
- epithelial mesenchymal transition
- pi k akt
- immune response
- induced apoptosis
- genome wide
- copy number
- mesenchymal stem cells
- high fat diet induced
- insulin resistance
- cell proliferation
- genome wide identification
- transcription factor