Juglone Mediates Inflammatory Bowel Disease Through Inhibition of TLR-4/NF KappaB Pathway in Acetic Acid-induced Colitis in Rats.
Neda Agha Alizadeh NobakhtNaser-Aldin LashgariNazanin Momeni RoudsariAmirhossein NiknejadDanial KhayatanSaeed TavakoliAli Reza AbdollahiNiusha EsmaealzadehSaeideh MomtazAmir Hossein AbdolghaffariPublished in: Anti-inflammatory & anti-allergy agents in medicinal chemistry (2023)
Juglone exhibited anti-inflammatory and antioxidant effects in the experimental colitis model and could be a therapeutic candidate for IBD. Juglone should be a subject for fur-ther animal and clinical trials in IBD models and for safety concerns.