Characterization of a Tigecycline-, Linezolid- and Vancomycin-Resistant Clinical Enteroccoccus faecium Isolate, Carrying vanA and vanB Genes.
Ewa WardalDorota ŻabickaTomasz SkalskiJoanna Kubiak-PulkowskaWaleria HryniewiczEwa SadowyPublished in: Infectious diseases and therapy (2023)
We provide the detailed characteristics of the genomic determinants of antimicrobial resistance of a clinical E. faecium demonstrating the concomitant presence of both vanA and vanB and resistance to vancomycin, linezolid, tigecycline and several other compounds and decreased daptomycin susceptibility. This isolate is a striking example of an accumulation of resistance determinants involving various mechanisms by a single hospital strain.
Keyphrases
- methicillin resistant staphylococcus aureus
- antimicrobial resistance
- acinetobacter baumannii
- staphylococcus aureus
- klebsiella pneumoniae
- healthcare
- genome wide
- copy number
- multidrug resistant
- gene expression
- drug resistant
- dna methylation
- pseudomonas aeruginosa
- emergency department
- cystic fibrosis
- transcription factor
- adverse drug
- genome wide analysis