Anticancer effects of the PLK4 inhibitors CFI-400945 and centrinone in Ewing's sarcoma cells.

Sophie L Kerschner-MoralesMarie KühneSabine BeckerJames F BeckJürgen Sonnemann

Published in: Journal of cancer research and clinical oncology (2020)

Our findings show that PLK4 inhibitors were effective against Ewing's sarcoma cells in vitro and thus provide a rationale for their evaluation in vivo.

Keyphrases

induced apoptosis
cell cycle arrest
clinical trial
signaling pathway
cell death
oxidative stress
pi k akt