Smac mimetics LCL161 and GDC-0152 inhibit osteosarcoma growth and metastasis in mice.

Tanmay M ShekharIngrid J G BurvenichMichael A HarrisAngela RigopoulosDamien ZankerAlex SpurlingBelinda S ParkerCarl R WalkleyAndrew M ScottChristine J Hawkins

Published in: BMC cancer (2019)

These data imply that Smac mimetics can cooperate with TNFα secreted by tumor-associated immune cells to kill osteosarcoma cells in vivo. Smac mimetics may therefore benefit osteosarcoma patients whose tumors contain Smac mimetic-responsive cancer cells and TNFα-producing infiltrating cells.

Keyphrases

induced apoptosis
cell cycle arrest
end stage renal disease
rheumatoid arthritis
ejection fraction
chronic kidney disease
peritoneal dialysis
type diabetes
cell death
signaling pathway
metabolic syndrome
drug delivery
high fat diet induced
pi k akt
cell proliferation
data analysis