Association of CYP2B6 Genetic Variation with Efavirenz and Nevirapine Drug Resistance in HIV-1 Patients from Botswana.
Monkgomotsi J MasengLeabaneng TawePrisca K ThamiKaelo K SeatlaSikhulile MoyoAxel MartinelliIshmael KasvosveVladimir NovitskyMax EssexGianluca RussoSimani GaseitsiweGiacomo Maria PaganottiPublished in: Pharmacogenomics and personalized medicine (2021)
We demonstrated that the CYP2B6 516G allele, and even more when combined in fast metabolic haplotypes, is associated with the presence of EFV/NVP resistance, strengthening the need to assess the CYP2B6 genetic profiles in HIV-infected patients in order to improve the virologic outcomes of NNRTI containing ART.
Keyphrases
- antiretroviral therapy
- hiv infected patients
- hiv infected
- hiv positive
- human immunodeficiency virus
- hiv aids
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- hepatitis c virus
- gene expression
- genome wide
- copy number
- patient reported outcomes
- adipose tissue
- insulin resistance
- weight loss