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Association of CYP2B6 Genetic Variation with Efavirenz and Nevirapine Drug Resistance in HIV-1 Patients from Botswana.

Monkgomotsi J MasengLeabaneng TawePrisca K ThamiKaelo K SeatlaSikhulile MoyoAxel MartinelliIshmael KasvosveVladimir NovitskyMax EssexGianluca RussoSimani GaseitsiweGiacomo Maria Paganotti
Published in: Pharmacogenomics and personalized medicine (2021)
We demonstrated that the CYP2B6 516G allele, and even more when combined in fast metabolic haplotypes, is associated with the presence of EFV/NVP resistance, strengthening the need to assess the CYP2B6 genetic profiles in HIV-infected patients in order to improve the virologic outcomes of NNRTI containing ART.
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