Single and repeated intra-articular injections in the tarsocrural joint with allogeneic and autologous equine bone marrow-derived mesenchymal stem cells are safe, but did not reduce acute inflammation in an experimental interleukin-1β model of synovitis.
Aimée C ColbathSteven W DowLeone S HopkinsJennifer N PhillipsC Wayne McIlwraithLaurie R GoodrichPublished in: Equine veterinary journal (2020)
This study revealed that allogeneic and autologous BMDMSCs resulted in an equivalent clinical and cytological response. Allogeneic and autologous BMDMSCs were equally ineffective in reducing the inflammatory response from acute rIL-1β-induced joint inflammation in horses.
Keyphrases
- bone marrow
- liver failure
- inflammatory response
- drug induced
- oxidative stress
- respiratory failure
- mesenchymal stem cells
- stem cell transplantation
- aortic dissection
- platelet rich plasma
- diabetic rats
- high glucose
- lipopolysaccharide induced
- cell therapy
- hepatitis b virus
- extracorporeal membrane oxygenation
- low dose
- hematopoietic stem cell
- intensive care unit
- acute respiratory distress syndrome
- mechanical ventilation