Wogonin, a Bioactive Ingredient from Huangqi Guizhi Formula, Alleviates Discogenic Low Back Pain via Suppressing the Overexpressed NGF in Intervertebral Discs.

Jitian LiWeifeng DuanShuang ChaiYage LuoYan MaNing YangMan LiuWei He

Published in: Mediators of inflammation (2023)

The HQGZ formula has significant analgesic effects for LBP. In addition, the bioactive ingredient of wogonin was extracted from HQGZ and ameliorated LBP by suppressing the overexpressed NGF in degenerated IVDs. Therefore, wogonin has potential to be alternative treatment for LBP in clinical.

Keyphrases

growth factor
human milk
signaling pathway
risk assessment
tissue engineering