Login / Signup

Synthesis of a Non-Symmetrical Disorazole C 1 -Analogue and Its Biological Activity.

Luca LizzadroOliver SpießSilke ReineckeMarc StadlerDieter Schinzer
Published in: Molecules (Basel, Switzerland) (2024)
The synthesis of a novel disorazole C 1 analogue is described, and its biological activity as a cytotoxic compound is reported. Based on our convergent and flexible route to the disorazole core, we wish to report a robust strategy to synthesize a non-symmetrical disorazole in which we couple one half of the molecule containing the naturally occurring oxazole heterocycle and the second half of the disorazole macrocycle containing a thiazole heterocycle. This resulted in a very unusual non-symmetrical disorazole C 1 analogue containing two different heterocycles, and its biological activity was studied. This provided exciting information about SAR (structure-activity-relationship) for this highly potent class of antitumor compounds.
Keyphrases
  • structure activity relationship
  • healthcare
  • social media
  • solid state
  • anti inflammatory