Synthesis and preclinical evaluation of [ 11 C]EAI045 as a PET tracer for imaging tumors expressing mutated epidermal growth factor receptor.

Antonia A HögnäsbackaAlex J PootChristophe PlissonJonas BergareDavid R BonsallStuart P McCluskeyLisa A WellsEsther KooijmanRobert C SchuitMariska VerlaanWissam BeainoGuus A M S van DongenDanielle J VugtsCharles S ElmoreJan PasschierAlbert D Windhorst

Published in: EJNMMI research (2024)

H]EAI045 in vitro in H1975 xenografts and cells.

Keyphrases

epidermal growth factor receptor
tyrosine kinase
induced apoptosis
advanced non small cell lung cancer
positron emission tomography
cell cycle arrest
pet imaging
high resolution
computed tomography
pet ct
endoplasmic reticulum stress
oxidative stress
cell therapy
signaling pathway
wild type
mesenchymal stem cells