Do the negative symptoms of schizophrenia reflect reduced responsiveness to reward? Examination using a reward prediction error (RPE) task.
Paola Fuentes-ClaramonteMaria Angeles Garcia-LeonPilar Salgado-PinedaNúria RamiroJoan Soler-VidalMaria Llanos TorresRamon CanoIsabel Argila-PlazaFrancesco PanicaliCarmen SarriNúria JaurrietaManel SánchezEster Boix-QuintanaAuria AlbaceteTeresa MaristanySalvador SarróJoaquim RaduàPeter J McKennaRaymond SalvadorEdith Pomarol-ClotetPublished in: Psychological medicine (2023)
The findings do not suggest that a generalized reduction of RPE signalling underlies negative symptoms. Instead, they point to a more circumscribed dysfunction in the lateral frontal and possibly the orbitofrontal cortex.