Targeted Next Generation Sequencing Revealed Novel Variants in the PKD1 and PKD2 Genes of Iranian Patients with Autosomal Dominant Polycystic Kidney Disease.

Maryam Hosseinpour Fariba Ardalani Marzieh Mohseni Maryam BeheshtianSanaz ArzhangiShahrzad OssarehHossein NajmabadiAli NobakhtKimia Kahrizi Behrooz Broumand

Published in: Archives of Iranian medicine (2022)

Our findings suggest that targeted gene panel sequencing is expected to be the method of choice to improve diagnostic and prognostic accuracy in PKD patients with heterogeneity in genetic background.

Keyphrases

polycystic kidney disease
copy number
genome wide
single cell
cancer therapy
dna methylation
genome wide identification
genome wide analysis
gene expression
circulating tumor
cell free