An isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS)-based candidate reference measurement procedure for the quantification of zonisamide in human serum and plasma.

Tobias SchierscherLinda SalzmannNeeraj SinghJanik WildVanessa FischerFriederike BaulandAndrea GeistangerLorenz RischChristian GeletnekyChristoph SegerJudith Taibon

Published in: Clinical chemistry and laboratory medicine (2023)

We present a novel LC-MS/MS-based candidate RMP for zonisamide in human serum and plasma which provides a traceable and reliable platform for the standardization of routine assays and evaluation of clinically relevant samples.

Keyphrases

liquid chromatography tandem mass spectrometry
simultaneous determination
ms ms
solid phase extraction
high throughput
minimally invasive