Aberrant naive CD4+ T cell differentiation in systemic juvenile idiopathic arthritis is committed to B cell help.
Julia KuehnSusanne SchleifenbaumMichaela HendlingSandra SiebenhandlJulie KrainerSabrina FuehnerAntje HelligeCarolin ParkClaas H HinzeHelmut WittkowskiDirk HolzingerLorenz ThurnerAndreas WeinhäuselDirk FoellChristoph KesselPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2022)
In sJIA pathogenesis skewing of sJIA naïve Th cell differentiation towards a Tf/ph phenotype may represent an echo of autoimmunity, which may indicate mechanisms driving the progression towards chronic destructive arthritis. This article is protected by copyright. All rights reserved.