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Melanoma brain metastases have lower T-cell content and microvessel density compared to matched extracranial metastases.

Sarah A WeissChristopher ZitoThuy TranKazuki HeishimaVeronique NeumeisterJohn McGuireAdebowale AdeniranHarriet KlugerLucia B Jilaveanu
Published in: Journal of neuro-oncology (2020)
Although responses to immune-modulating drugs in the body and the brain tend to be concordant, differences were found in MVD and T-cell content between these sites. Studies of these markers should be incorporated into prospective therapeutic clinical trials to determine their prognostic and predictive value.
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