High doses of zoledronic acid induce differential effects on femur and jawbone microstructure.
Mariana Q S SoaresJeroen Van DesselReinhilde JacobsGustavo Z FerreiraPaulo Sérgio da Silva SantosLaura Ferreira Pinheiro NicolieloMarco Antonio Hungaro DuarteIzabel Regina Fischer Rubira-BullenPublished in: Clinical and experimental dental research (2022)
High doses of bisphosphonates can differently affect the bone quantity, density, and structure in long bones and jawbones. In the metaphysis, bone changes were primarily concentrated in the region of the growth plate. Future studies may consider the use of bone morphometric indices to evaluate the effect of bisphosphonates.