Clinical outcomes and longitudinal circulating tumor DNA changes after treatment with nivolumab and olaparib in immunotherapy relapsed melanoma with detected homologous recombination deficiency.
Karam KhaddourMichael AnsstasGeorge AnsstasPublished in: Cold Spring Harbor molecular case studies (2021)
The treatment of immunotherapy relapsed cutaneous melanoma constitutes a challenge in both research and clinical practice fields given the lack of effective therapeutic options. Homologous recombination deficiency (HRD) has been identified in several solid cancers including cutaneous melanoma. However, the utility of medications targeting HRD cancer cells is an uncharted territory in melanoma. Moreover, preclinical evidence suggests a synergistic role of combining immune checkpoint blockade (ICB) with drugs targeting HRD cancer cells such as PARP inhibitors. Here, we present a case study of a patient with immunotherapy relapsed melanoma who was found to have detected HRD and was treated with nivolumab (ICB) and olaparib (PARP inhibitors).
Keyphrases
- dna repair
- dna damage
- circulating tumor
- acute lymphoblastic leukemia
- acute myeloid leukemia
- skin cancer
- diffuse large b cell lymphoma
- multiple myeloma
- hodgkin lymphoma
- clinical practice
- cancer therapy
- cell free
- basal cell carcinoma
- stem cells
- oxidative stress
- case report
- replacement therapy
- single molecule
- bone marrow
- mesenchymal stem cells
- combination therapy