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Low leukocyte mitochondrial DNA abundance drives atherosclerotic cardiovascular diseases: cohort and Mendelian randomization study.

Jiao LuoRaymond NoordamJ Wouter JukemaKo Willems van DijkSara HäggFelix GrassmannSaskia Le CessieDiana van Heemst
Published in: Cardiovascular research (2022)
Our findings support a possible causal role of lower leukocyte mtDNA abundance in higher CAD risk, but not in HF.
Keyphrases
  • mitochondrial dna
  • copy number
  • cardiovascular disease
  • antibiotic resistance genes
  • coronary artery disease
  • peripheral blood
  • genome wide
  • type diabetes
  • heart failure
  • cardiovascular risk factors
  • wastewater treatment