An Integrated Analysis of Network Pharmacology and Experimental Validation to Reveal the Mechanism of Chinese Medicine Formula Naotaifang in Treating Cerebral Ischemia-Reperfusion Injury.

Tong YangXiangyu ChenZhi-Gang MeiXiaolu LiuZhitao FengJun LiaoYihui DengJin-Wen Ge

Published in: Drug design, development and therapy (2021)

This network pharmacological and experimental study indicated that NTF, as a therapeutic candidate for the management of CIRI following ischemic stroke, may exert a protective effect through the STAT3/PI3K/AKT signaling pathway.

Keyphrases

pi k akt
signaling pathway
cell proliferation
ischemia reperfusion injury
cell cycle arrest
induced apoptosis
epithelial mesenchymal transition
oxidative stress
genome wide
atrial fibrillation
network analysis
gene expression
cell death
single cell
blood brain barrier
preterm infants
preterm birth