Sequential alterations in diffusion metrics as correlates of disease severity in amyotrophic lateral sclerosis.
Hans-Peter MüllerAnna BehlerMaximilian MünchJohannes DorstAlbert C LudolphJan KassubekPublished in: Journal of neurology (2023)
The progression of white matter alterations across tracts according to the model of sequential tract involvement is associated with clinical disease severity in patients with ALS, suggesting the use of staging-based DTI as a technical marker for disease progression.