Cerebrospinal fluid β-glucocerebrosidase activity is reduced in parkinson's disease patients.

Lucilla ParnettiSilvia PaciottiPaolo EusebiAndrea DardisStefania ZampieriDavide ChiasseriniAnna TasegianNicola TambascoBruno BembiPaolo CalabresiTommaso Beccari

Published in: Movement disorders : official journal of the Movement Disorder Society (2017)

CSF β-glucocerebrosidase activity is reduced in PD patients independent of their GBA1 mutation carrier status. Cathepsin D and β-hexosaminidase were also decreased. The possible link between altered CSF lysosomal enzyme activities and cognitive decline deserves further investigation. © 2017 International Parkinson and Movement Disorder Society.

Keyphrases

cognitive decline
end stage renal disease
cerebrospinal fluid
ejection fraction
newly diagnosed
prognostic factors
mild cognitive impairment
patient reported outcomes
patient reported