Quercetin shows anti-tumor effect in hepatocellular carcinoma LM3 cells by abrogating JAK2/STAT3 signaling pathway.

Liwei WuJingjing LiTong LiuSainan LiJiao FengQiang YuJie ZhangJiaojiao ChenYuting ZhouJie JiKan ChenYuqing MaoFan WangWeiqi DaiXiaoming FanJianye WuChuan-Yong Guo

Published in: Cancer medicine (2019)

Quercetin inhibited hepatocellular carcinoma progression by modulating cell apoptosis, migration, invasion, and autophagy; and its effects were at least partly related with the JAK2/STAT3 signaling pathway.

Keyphrases

signaling pathway
induced apoptosis
pi k akt
cell cycle arrest
endoplasmic reticulum stress
epithelial mesenchymal transition
cell proliferation
oxidative stress
cell death