Impact of Previously Unrecognized HLA Mismatches Using Ultrahigh Resolution Typing in Unrelated Donor Hematopoietic Cell Transplantation.
Neema P MayorTao WangStephanie J LeeMichelle KuxhausenCynthia Vierra-GreenDominic J BarkerJeffrey AulettaVijaya Raj BhattShahinaz M GadallaLoren GragertYoshihiro InamotoGerald P MorrisSophie PaczesnyRan ReshefOlle RingdénBronwen E ShawPeter J ShawStephen R SpellmanSteven G E MarshPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2021)
This study did not confirm that UHR 12 out of 12 HLA matching increases the probability of overall survival but does demonstrate that aGVHD risk, and in certain settings TRM, is lowest in UHR HLA-matched pairs and thus warrants consideration when multiple 10 out of 10 HLA-matched donors of equivalent age are available.