Fitting NTCP models to bladder doses and acute urinary symptoms during post-prostatectomy radiotherapy.

Panayiotis MavroidisKevin A PearlsteinJohn DooleyJasmine SunSrinivas SaripalliShiva K DasAndrew Z WangRonald C Chen

Published in: Radiation oncology (London, England) (2018)

Different dose metrics were correlated with the symptoms of urgency, incontinence, frequency and nocturia. The symptoms of urinary flow and dysuria were poorly associated with dose. The values of the parameters of three NTCP models were determined for bladder regarding four acute urinary symptoms. All the models could fit the clinical data equally well. The NTCP predictions of urgency showed the best correlation with the patient reported outcomes.

Keyphrases

patient reported outcomes
liver failure
sleep quality
spinal cord injury
respiratory failure
early stage
drug induced
urinary incontinence
radiation therapy
electronic health record
intensive care unit
radiation induced
urinary tract
deep learning