Optimization of antimicrobial dosing in patients with acute kidney injury: a single-centre observational study.

Stephen HughesKatie L HeardNabeela MughalLuke Stephen Prockter Moore

Published in: JAC-antimicrobial resistance (2022)

There is a high burden of AKI in patients with Gram-negative bacteraemia. Dose adjustments of β-lactams may not be necessary in the first 48 h of infection-induced AKI and single-dose aminoglycosides may be considered for early empirical coverage.

Keyphrases

acute kidney injury
gram negative
multidrug resistant
cardiac surgery
high glucose
staphylococcus aureus
diabetic rats
drug induced
oxidative stress
affordable care act
healthcare
risk factors
endothelial cells
stress induced